RS2000系列生物學(xué)X-ray輻照儀，可以直接取代傳統(tǒng)銫和鈷源同位素輻照儀。在劑量均一性、安全性、穩(wěn)定性、試驗重復(fù)性等方面更為優(yōu)秀，已成為生命科學(xué)研究領(lǐng)域中的重要*科研工具！目前，歐美各國的生物醫(yī)學(xué)科研機(jī)構(gòu)已較少選擇同位素輻照儀，而綠色環(huán)保、劑量均勻性更佳的Rad Source公司細(xì)胞與動物X-ray輻照儀已成為科研領(lǐng)域*；
RS2000系列生物學(xué)X-ray輻照儀，擁有眾多科技：反射樣品室、高安全性屏蔽技術(shù)、射線束過濾技術(shù)、雜射線濾出裝置、簡化易操作觸控技術(shù)、業(yè)內(nèi)zui高的劑量均一性，劑量均一性約為±2.5%，業(yè)內(nèi)*一款≥95%；劑量率可調(diào):0.1~16Gy/min（=10~1600rad/min =10~1600cGy/min）；
創(chuàng)新--Patented* RAD+ chamber --* Patent No; 6,389,099
Rad Source uses validations from NIST to validate their equipment. In the case of our laboratory irradiators (RS 2000) the AAPM guide to laboratory calibration is used. In either case output from Rad Source irradiators is calibrated to international standards insuring its performance anywhere in the world；
RAD SOURCE為生物學(xué)X射線輻照儀領(lǐng)域世界，*科研機(jī)構(gòu)*產(chǎn)品，RAD SOURCE被認(rèn)為是高精密、*輻照技術(shù)及高質(zhì)量的代表，性能穩(wěn)定，擁有zui大的*與科研用戶的好評。
RAD SOURCE RS2000系列產(chǎn)品不但成為了美國本土科研機(jī)構(gòu)的*，也得到了世界多國高水平科研機(jī)構(gòu)的廣泛認(rèn)可，如：德國、法國、英國、瑞士、意大利、日本、新加坡等；在300多家*研究機(jī)構(gòu)和生物制藥研發(fā)企業(yè)中運(yùn)轉(zhuǎn)，其性能和品質(zhì)得到了市場的充分驗證；輻照儀從2009年起正式供應(yīng)中國科研機(jī)構(gòu)，已被30多家科研平臺所選用，性能和品質(zhì)也得到了國內(nèi)用戶的廣泛認(rèn)可。
RS2000系列，廣泛應(yīng)用于以下各研究領(lǐng)域
飼養(yǎng)層細(xì)胞
干細(xì)胞
骨髓移植
腫瘤學(xué)
免疫學(xué)
DNA損傷相關(guān)
信號轉(zhuǎn)導(dǎo)
基因組學(xué)
放射生物學(xué)
小動物輻照
藥物研發(fā)
等生物醫(yī)學(xué)領(lǐng)域
Welcome to RAD Source
Since 1997 Rad Source Technologies has been the expert in providing renewable, non-isotope, ionizing radiation replacements for self-shielded gamma irradiators. Currently, there are over 300 renowned hospital, university, and pharmaceutical research institutions using Rad Source X-ray technology. To find out more about our equipment, select your application and you will find equipment specifications, literature references, white papers, training videos, discussion forums, as well as other helpful info；
REASONS WHY THE
RAD SOURCE RS 2000 X-RAY IRRADIATOR
IS THE SYSTEM OF CHOICE FOR YOUR
RESEARCH AND BIOLOGICAL IRRADIATION REQUIREMENTS
The RS 2000 is a research & biological irradiator that features the following advantages:
The RS 2000 is self-contained and requires no external cooling system
NO Nuclear Site license or secure/shielded room is needed
The RS 2000 is ideal for small animal research when using our patented RAD + reflective cage enclosure. This unique and patented feature provides for a dose rate within the cage of 1.2 Gy/min (120 rads/min or the same as gamma irradiator) and the dose distribution is better than 94% across the entire field (much better than a gamma irradiator). The RAD+ is designed to hold one standard Allentown filtered rearing cage. (Three of which are supplies with the system.) This feature improves animal husbandry by allowing transport and irradiation of the animals inside a filtered environment mitigating cross-contamination issues. Because the animals are irradiated in their cage, multiple mice can be irradiated during one cycle. IF itis important for you to have reproducible results that equate to theirradiation standard of Cesium - the only choice is the RS 2000 with .3mm of Copper filter irradiating at 160 kV AT 25 mA (NEW 225 kV available).
The RS 2000 is ideal for targeted tumor irradiation using our spot beam collimator or custom animal shielding and offers variable dose rates to the target.
For Cells and other research the RS 2000 has dose rates of >5 Gy/min (500 rads/min.) filtered and up to >17 Gy/min unfiltered.
This is the only system available that allows for 160 kV operation @ 25 mA (not “AND or OR” but AT 25 mA)
“Plug and Play” installation: Installation, dose-mapping & in-service in one day.
Mounted on wheels
Footprint 33” X 42” (82.8 cm X 106.7 cm) and weighs 1250 lbs (567 kg).
Simple touch screen operators’ panel for ease of use and operation.
Please review the information on our website: www.radsource。。ｃｏｍ
Rad Source is the recognized expert in the field of x-ray irradiation. We developed the only US-FDA approved blood irradiator for replacing Cs irradiators and are the leaders in high dose, high volume irradiation systems worldwide
The RS 2000 should be the choice for your next
professional quality biological and research irradiator
Features
· “Plug and Play” Installation
· Unit is mounted on caster wheels for easy movement
· Self-contained cooling
· Easy access to built-in calibration port
· Specialized filtration eliminates lower energy X-rays
· Optimal for split-dose delivery
· Easy to use touch screen operation
· CE Marked & Compliant
· Renewable Ionizing Radiation
· No NRC License Required
· No shielded or secure room required
· No disposal costs
部分科研機(jī)構(gòu)文獻(xiàn)
RAD SOURCE RS2000系列產(chǎn)品得到了廣泛應(yīng)用，文獻(xiàn)發(fā)表在以下期刊：Cancer Res.、BLOOD、PANS、CELL、Stem Cell Biology、JEM、Nature、The Journal of Immunology、Hematology and Stem Cells、Stem Cells、PLoS Biology、Liver、I Int. J. Biol. Sci.、THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS、MOLECULAR AND CELLULAR BIOLOGY、Experimental Hematology等。
1、DNA damage checkpoint control in cells exposed to ionizing radiation
NATURE
George Iliakis*,1, Ya Wang2, Jun Guan2 and Huichen Wang2
1Institute of Medical Radiation Biology, University of Essen Medical School, Hufelanstrasse 55, 45122 Essen, Germany; 2Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
2、Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
CELL
Centre de recherche CHU Ste-Justine, Montre´ al, QC, Canada； 2Lawrence Berkeley National Laboratory, Berkeley, CA, USA
3Buck Institute for Age Research, Novato, CA, USA；4Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, CO, USA
3、Nuclear Localization of p38 MAPK in Response to DNA Damage
I Int. J. Biol. Sci. 2009, 5
C. David Wood1, Tina M. Thornton1, Guadalupe Sabio2, Roger A. Davis2,
1. Department of Medicine/Immunobiology Program, University of Vermont, Burlington, VT 05405. USA.
2. Program in Molecular Medicine, University of Massachusetts, Worcester, MA 01605.Correspondence to: Mercedes Rincon
Received: 2009.04.30; Accepted: 2009.06.10; Published: 2009.06.16
4、Passive and Active Mechanisms Trap Activated CD8+ T Cells in the ...
The Journal of Immunology
Six- to 8-wk-old mice were irradiated with 1000 rad (10 Gy) as a single dose from an RS2000
x-ray irradiator (Rad Source; Rad Source Technologies, Coral Springs, FL) and used as recipients.
Mature T cells were depleted from donor bone ...
www.jimmunol。。ｏｒｇ/cgilcontent/full/172/9/5222
5、Expression of common chromosomal fragile site genes, VVWOX/FRA 16D ..
MOLECULAR CARCINOGENESIS
fluency were irradiated in RS2000 X-ray Irradiator. (Rad Source Technologies, Inc., Boca Raton, FL). Control cells were sham-irradiated in both the UV-. C and ionizing radiation (IR) experiments. For BPDE. treatment,8t-dihydroxy-9 ... doLwiley.com
6、Complete differentiation of CD8+ T cells activated locally within ...
JEM
6 8-wk-old recipient mice were irradiated with a dose of 10 Gy (1000 rad) using an RS2000 X-ray irradiator (RadSource Technologies). Depletion of mature T lymphocytes from donor bone marrow cells was achieved by incubation with anti-CD4 ...
7、An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
BLOOD
Monica L. Guzman,1 Randall M. Rossi,1 Sundar Neelakantan,2 Xiaojie Li,1 Cheryl A.
8、Ku86 Modulates DNA Topoisomerase I–Mediated Radiosensitization, but not Cytotoxicity, in Mammalian Cells
Cancer Res 2005
Shyh-Jen Shih, Tara Erbele, and Allan Y. Chen
Department of Radiation Oncology, University of California Davis Medical Center, Sacramento,California
9、Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal Inflammation
PANS
Simona Zarini1, Miguel A. Gijo´ n1, Aaron E. Ransome, Robert C. Murphy2
Department of Pharmacology, University of Colorado Denver, Mail Stop 8303, 12801 East 17th Avenue, Aurora Communicated by K. Frank Austen, Brigham and Women’s Hospital, Boston, MA, April 7, 2009 (received for review February 23, 2009)
10、Irradiation Selects for p53-Deficient Hematopoietic Progenitors
PLoS Biology
Andriy Marusyk1,2¤, Christopher C. Porter1,3, Vadym Zaberezhnyy1 DeGregori1,2,3,4*
Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America, 2 Program in Molecular Biology, University of Colorado Denver School of Medicine, Aurora, Colorado, United States of America
11、Kupffer cell heterogeneity: functional properties of bone marrow–derived and sessile hepatic
macrophages
BLOOD
Ingo Klein, 1,2 Judith C. Cornejo,3 Noelle K. Polakos,2 Beena John,2 Sherry A.
1David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical
Research, University of Rochester School of Medicine and Dentistry, NY;
Received February 11, 2007; Accepted July 25, 2007.
12、Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors
Cancer Res 2009
Andriy Marusyk,1,2 Matias Casa′s-Selves,1,2 Curtis J. Henry,1,4 Vadym Zaberezhnyy,1
Jelena Klawitter,5 Uwe Christians,5 and James DeGregori1,2,3,4
1Department of Biochemistry and Molecular Genetics, 2Program in Molecular Biology,
3Department of Pediatrics, 4Integrated
Department of Immunology; and 5Department of Anesthesiology, University of Colorado
Denver School of Medicine, Aurora, Colorado
13、Progression of Pancreatic Adenocarcinoma Is Significantly Impeded with a Combination of
Vaccine and COX-2 Inhibition1
The Journal of Immunology
Pinku Mukherjee,2* Gargi D. Basu,† Teresa L. Tinder,* Durai B. Subramani,*
Judy M. Bradley,* Million Arefayene,‡ Todd Skaar,‡ and Giovanni De Petris§
