Description
Application Reagent for the covalent modification of cysteine residues in proteins.
Biochem/physiol Actions Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
Preparation Note NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water （>50 mg in 4 ml）; however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Properties
assay ≥98% （HPLC）
form crystalline
bp 210 °C（lit.）
mp 43-46 °C（lit.）
Gene Information human ... KCNQ2（3785）, KCNQ4（9132）, KCNQ5（56479）, SLC6A3（6531）, SLC6A4（6532）
storage temp. 2-8°C
中文名稱: N-乙基馬來酰亞胺
中文同義詞: 1-乙基-1H-吡咯-2,5-二酮;N-乙基馬來酰亞胺;N-乙基失水蘋果酰亞胺;N-乙基順丁烯二酰亞胺;N-乙基順丁烯二酰亞胺（NEM）;N-乙基馬來酰亞胺, 99+%;N-乙基馬來酰亞胺, 98+%
英文名稱: N-Ethylmaleimide
英文同義詞: 1-ethyl-1h-pyrrole-5-dione;5-dione,1-ethyl-1H-Pyrrole-2;ethvlmaleimide;Ethylmaleimide;Maleic acid N-ethylimide;maleicacidn-ethylimide;Maleimide, N-ethyl-;n-ethvlmaleimide
CAS號: 128-53-0
分子式: C6H7NO2
分子量: 125.13
