P物質(zhì)抗體Substance P相關(guān)標(biāo)記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC      
英文名稱    Substance P
中文名稱    P物質(zhì)抗體
別    名    Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; Neuropeptide K; NK2; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.
研究領(lǐng)域    神經(jīng)生物學(xué)  新陳代謝  
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應(yīng)    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, G
P物質(zhì)抗體Substance P產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    1.4kDa
細(xì)胞定位    分泌型蛋白 
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human Substance P (RPKPFFGLM)
亞    型    IgG
純化方法    affinity purified by Protein A
儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed    PubMed
產(chǎn)品介紹    background:
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Subcellular Location:
Secreted.

Similarity:
Belongs to the tachykinin family.

Gene ID:
6863

Database links:
Entrez Gene: 6863 Human
Entrez Gene: 21333 Mouse
Entrez Gene: 24806 Rat
Omim: 162320 Human
SwissProt: P20366 Human
SwissProt: P41539 Mouse
SwissProt: P06767 Rat
Unigene: 2563 Human
UniProtKB/Swiss-Prot: P20366.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

P物質(zhì)（Substance P）是腦組織及消化道中發(fā)現(xiàn)的一種神經(jīng)遞質(zhì)肽。由130個氨基酸殘基組成，胃腸道中肌肉收縮的有力促進劑，亦為強血管擴張劑。
SP是一種腦腸肽，亦是zui早發(fā)現(xiàn)的一種神經(jīng)肽，屬于速激肽家族成員，它廣泛分布于中樞及外周神經(jīng)系統(tǒng)，作為一種神經(jīng)遞質(zhì)或調(diào)質(zhì)參與疼痛、免疫、心血管等多種生理功能的調(diào)節(jié)。SP與其它的遞質(zhì)或調(diào)質(zhì)類似，能作用于多種類型的受體，速激肽家族有NK1、NK2、NK3三種受體，都能與SP結(jié)合，其中NK1與SP的結(jié)合能力zui強而被稱為SP受體。
產(chǎn)品圖片    
Antigen: bs-0065P, 0.2ug/100ul 
Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; 
Secondary: HRP conjugated Goat-Anti- Rabbit IgG(bs-0295G-HRP) at 1: 5000; 
TMB(C-0024) staining; 
Read the data in MicroplateReader by 450nm.