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Anti-phospho-ATF2(Thr71+Thr53)抗體,磷酸化活化復制因子2抗體

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更新時間:2015-04-09 09:07:33瀏覽次數(shù):131次

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博研生物強烈*“Anti-phospho-ATF2(Thr71+Thr53)抗體,磷酸化活化復制因子2抗體",品質(zhì)保障,*,提供,實驗無結果可免費退換!:

詳細介紹

Anti-phospho-ATF2(Thr71+Thr53)抗體,磷酸化活化復制因子2抗體產(chǎn)品介紹:ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

保存條件:  Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The  lyophilized antibody is stable at room temperature for at least one month and for greater  than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent  of antibody, the antibody is stable for at least six weeks at 2-4 ℃

重要提示: 本產(chǎn)品提供僅供研究使用,不用于人類治療或診斷.


產(chǎn)品名稱:Anti-phospho-ATF2(Thr71+Thr53)抗體,磷酸化活化復制因子2抗體

產(chǎn)品編號:BYK-12541R

產(chǎn)品規(guī)格:0.1ml/0.2ml

產(chǎn)品價格:請

性 狀:Lyophilized or Liquid

濃 度:1mg/1ml

亞 型:IgG

貯 存:貯存于-20℃.

抗體來源:本公司抗體有兔來源和鼠來源等

克隆類型:兔來源為多抗,鼠來源為單抗

產(chǎn)品類型:一抗

此抗體本公司有單抗和多抗,可用于免疫組化(IHC),免疫印跡(WB),酶聯(lián)免疫(ELISA),IF、IP、流式細胞術等實驗(可來電索取說明)

此產(chǎn)品本公司有標記的一抗出售,相關標記有:Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記


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