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聯(lián)系我時，請告知來自 環(huán)保在線博研生物強烈*“Anti-Beta catenin抗體,β連環(huán)蛋白/β連環(huán)素抗體-產(chǎn)品介紹"，品質(zhì)保障，*，提供，實驗無結(jié)果可免費退換?。?/p>
產(chǎn)品名稱：Anti-Beta catenin抗體,β連環(huán)蛋白/β連環(huán)素抗體-產(chǎn)品介紹
產(chǎn)品編號：BYK-1165R
產(chǎn)品規(guī)格：0.1ml/0.2ml
英文名稱 Beta catenin
中文名稱 β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
別 名 beta-catenin; beta catenin; CTNNB1; CHBCAT; CTNNB1; CTNNB; PRO2286; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; b-catenin; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289;
研究領(lǐng)域 腫瘤 細胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細胞
抗體來源：本公司抗體有兔來源和鼠來源等
克隆類型：兔來源為多抗，鼠來源為單抗
產(chǎn)品類型：一抗
此抗體本公司有單抗和多抗，可用于免疫組化（IHC），免疫印跡（WB），酶聯(lián)免疫(ELISA)，IF、IP、流式細胞術(shù)等實驗（可來電索取說明）
此產(chǎn)品本公司有標記的一抗出售，相關(guān)標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記
Anti-Beta catenin抗體,β連環(huán)蛋白/β連環(huán)素抗體-產(chǎn)品介紹產(chǎn)品介紹：The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Function:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
,β連環(huán)蛋白/β連環(huán)素抗體-產(chǎn)品介紹優(yōu)勢產(chǎn)品：
Anti-beta Adaptin/AP2/FITC 熒光素標記銜接蛋白β抗體IgG
Anti-γ-Adaptin/FITC 熒光素標記銜接蛋白γ抗體IgG
Anti-AP1/FITC 熒光素標記銜接蛋白1抗體IgG
Anti-Apaf-1 /FITC 熒光素標記凋亡蛋白活性因子-1抗體（C端）IgG
Anti-Apaf-1/FITC 熒光素標記凋亡蛋白活性因子-1抗體（N端）IgG
Anti-APC/FITC 熒光素標記APC活化蛋白C抗體IgG
Anti-APCDD1/FITC 熒光素標記腺瘤息肉調(diào)節(jié)蛋白抗體IgG
Anti-Apelin/FITC 熒光素標記脂肪炎癥因子Apelin抗體IgG
Anti-Apelin receptor/APJ receptor /FITC 熒光素標記Apelin receptor抗體IgG
Anti-APEX1/Ref-1 /FITC 熒光素標記氧化還原因子1抗體IgG
Anti-APG4B/AUTL1 /FITC 熒光素標記APG4B細胞自噬相關(guān)抗體IgG
Anti-API5/AAC11 /FITC 熒光素標記凋亡抑制因子5抗體IgG
Anti-APNG/MPG/FITC 熒光素標記N-甲基嘌呤DNA糖基化酶IgG
Anti-apoA1/FITC 熒光素標記載脂蛋白A1抗體IgG
Anti-apo-D /FITC 熒光素標記載脂蛋白D抗體IgG
Anti-Apo-E/FITC 熒光素標記載脂蛋白E抗體IgG
Anti-ApoH/FITC 熒光素標記載脂蛋白H抗體IgG
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