凝固酶陽性與凝固酶陰性葡萄球菌之間的傳統(tǒng)區(qū)分方法是通過試管法凝固酶試驗來檢測胞外葡萄球菌凝固酶，或通過玻片法凝固酶試驗來檢測細菌細胞表面的凝集因子（結(jié)合凝固酶）。據(jù)報告，約 97% 的人類菌株同時具有結(jié)合凝固酶和細胞外葡萄球菌凝固酶。蛋白質(zhì) A 存在于約 95% 的人類菌株的細胞表面，并且具有結(jié)合免疫球蛋白 G (IgG)1 的 Fc 部分的能力。
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