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上海暄泓科學(xué)儀器有限公司
上海暄泓科學(xué)儀器有限公司
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XSelect HSS C18 SB 柱是超高效通用性C18色譜柱，用于提供對堿性分析物的優(yōu)異峰形、提高保留(相對于BEH C18柱)，以及在低pH條件下的極長柱壽命。HSS C18柱所表現(xiàn)出的選擇性與保留性與大多數(shù)現(xiàn)代全封端的硅膠C18色譜柱色譜行為較為相近。
Development and validation of new RP-HPLC method for the determination of gliclazide in tablet dosage form
A new sensitive and economic analytical method for the analysis of gliclazide in tablet dosage form was developed and validated using commercial HPLC instrument with modern ultra-performance liquid chromatography column. Samples were analysed using Agilent 1100 Series RP-HPLC equipped with a binary pump and auto injector. Samples were injected into Xselect HSS C18 XP column (2.1 × 100 mm, 2.5 μm), 2.5 μm) and the phase consisted of triethylamine buffer 0.3% (pH = 3 adjusted using phosphoric acid) and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.4 mL/min and the DAD detector was used for the detection and the wavelength was 229 nm. The method was validated according to ICH guidelines. The retention time for gliclazide peak was 3.437 ± 0.41 min with the total run time of 6 min with total solvent consumption of 2.4 mL per run. The method was found linear over the range 0.1-10 μg/mL with coefficient of determination R2 of 0.9997. The recovery was 98.09-100.19 %, and the method showed high precision and repeatability. Degradation pathway of gliclazide was studied following different types of stress degradation which are base, acid, UV, and oxidization. All validated parameters were in the acceptable range of ICH requirements. In conclusion, a new, rapid, sensitive, and economic method was developed and validated for the analysis of gliclazide in tablet dosage form. ? 2017, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.
品名 | 編號 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 50 mm, 1/pkg | 186006422 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 30 mm, 1/pkg | 186006421 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 100 mm, 1/pkg | 186006424 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 75 mm, 1/pkg | 186006423 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 2.1 mm X 150 mm, 1/pkg | 186006425 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 75 mm, 1/pkg | 186006428 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 50 mm, 1/pkg | 186004753 |
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 150 mm, 1/pkg | 186006434 |
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 100 mm, 1/pkg | 186006433 |
XSelect HSS C18 SB Column, 100?, 5 µm, 1 mm X 150 mm, 1/pkg | 186006419 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 150 mm, 1/pkg | 186004744 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 100 mm, 1/pkg | 186004743 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 150 mm, 1/pkg | 186004749 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 30 mm, 1/pkg | 186004752 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 100 mm, 1/pkg | 186004748 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 4.6 mm X 250 mm, 1/pkg | 186004751 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 50 mm, 1/pkg | 186004747 |
XSelect HSS C18 SB Column, 100?, 3.5 µm, 3 mm X 30 mm, 1/pkg | 186004746 |
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 250 mm, 1/pkg | 186006440 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 30 mm, 1/pkg | 186006442 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 100 mm, 1/pkg | 186006444 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 75 mm, 1/pkg | 186006443 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 250 mm, 1/pkg | 186004756 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186004754 |
XSelect HSS C18 SB Column, 100?, 5 µm, 4.6 mm X 50 mm, 1/pkg | 186004757 |
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 30 mm, 1/pkg | 186006431 |
XSelect HSS C18 SB Column, 100?, 5 µm, 2.1 mm X 50 mm, 1/pkg | 186006432 |
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 100 mm, 1/pkg | 186006438 |
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 150 mm, 1/pkg | 186006439 |
XSelect HSS C18 SB Column, 100?, 5 µm, 3 mm X 50 mm, 1/pkg | 186006437 |
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