IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 5µCi

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產(chǎn)品簡介

Interferon gamma-induced protein 10 (IP-10; CXCL10), labeled with 125I. IP-10 binds the chemokine CXCR3 receptor, and is secreted in response to IFN-γ.

詳細(xì)介紹

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX348:

Gao, J.M., Xiang, R.L., Jiang, L., Li, W.H., Feng, Q.P., Guo, Z.J., Sun, Q., Zeng, Z.P., Fang, F.D. (2009), Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. Acta Pharmacol Sin., 30 (2): 193-201.
Jenh, C.H., Cox, M.A., Hipkin, W., Lu, T., Pugliese-Sivo, C., Gonsiorek, W., Chou, C.C., Narula, S.K., Zavodny, P.J. (2001), Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Cytokine, 15 (3): 113-121.

規(guī)格

濃度	41.4 µCi/mL
檢測方法	Radiometric
新鮮的很多天	Third Monday of each month
標(biāo)簽位置	Nominally Labeled
產(chǎn)品品牌名稱	NEN Radiolabeled Ligands
放射性同位素	I-125
放射性核素	¹²⁵I
受體類型	Chemokine
運輸條件	干冰
特殊訂購信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域	Inflammation
產(chǎn)品尺寸	5 µCi