齊一生物科技(上海)有限公司作者
妊娠相關(guān)血漿蛋白A2抗體詳細(xì)
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關(guān) 鍵 詞 | 妊娠相關(guān)血漿蛋白A2抗體詳細(xì) |
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相關(guān)標(biāo)記
Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5
Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC
英文名稱(chēng)
PAPP A2
中文名稱(chēng)
妊娠相關(guān)血漿蛋白A2抗體
別 名
PAPPA 2; PAPP E; PAPP-A2; PAPP-E; PAPP2_HUMAN; PAPPA 2; PAPPA2; Pappalysin 2; Pappalysin-2; PLAC3; Pregnancy associated plasma protein A2; Pregnancy associated plasma protein E1; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1.
研究領(lǐng)域
心血管 細(xì)胞生物 泛素
抗體來(lái)源
Rabbit
克隆類(lèi)型
Polyclonal
交叉反應(yīng)
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
產(chǎn)品應(yīng)用
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量
173kDa
細(xì)胞定位
分泌型蛋白
性 狀
Lyophilized or Liquid
濃 度
1mg/1ml
免 疫 原
KLH conjugated synthetic peptide derived from human PAPP A2
亞 型
IgG
純化方法
affinity purified by Protein A
儲(chǔ) 存 液
Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed
PubMed
產(chǎn)品介紹
background:
Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.
Function:
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.
Subunit:
Monomer.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
Similarity:
Belongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains.
Database links:Entrez Gene: 60676 Human
Entrez Gene: 23850 Mouse
Entrez Gene: 364027 Rat
SwissProt: Q9BXP8 Human
Unigene: 187284 Human
Unigene: 458621 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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