流感病毒是現(xiàn)今可以致命的呼吸道病毒，機(jī)體的殺傷細(xì)胞NK在抵抗流感病毒中發(fā)揮著非常重要的作用。NKp46受體是由NK細(xì)胞產(chǎn)生用于防止病毒感染的。當(dāng)細(xì)胞被感染的時(shí)候，病毒產(chǎn)生的血凝集素蛋白會(huì)被NKp46所識(shí)別，然后NKp46結(jié)合NK細(xì)胞的NKp46受體，進(jìn)而激活免疫，并清除受感染的細(xì)胞，從而消滅病毒。

在該研究中，研究人員通過(guò)體內(nèi)和體外兩個(gè)方面揭示了流感病毒神經(jīng)氨酸酶介導(dǎo)的免疫逃逸機(jī)制。同時(shí)也證明了用于流感病毒感染治療的NA抑制劑可以抑制病毒的繁殖，同時(shí)促進(jìn)NKp46對(duì)于病毒的識(shí)別，進(jìn)而加強(qiáng)免疫。

Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses

Yotam Bar-On,Ariella Glasner,Tal Meningher,Hagit Achdout,Chamutal Gur,Dikla Lankry,Alon Vitenshtein,Adrienne F.A. Meyers,Michal Mandelboim,Ofer Mandelboim

Natural killer （NK） cells play an essential role in the defense against influenza virus, one of the deadliest respiratory viruses known today. The NKp46 receptor, expressed by NK cells, is critical for controlling influenza infections, as influenza-virus-infected cells are eliminated through the recognition of the viral hemagglutinin （HA） protein by NKp46. Here, we describe an immune-evasion mechanism of influenza viruses that is mediated by the neuraminidase （NA） protein. By using various NA blockers, we show that NA removes sialic acid residues from NKp46 and that this leads to reduced recognition of HA